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EPOPROSTENOL
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DeCS
Descriptor
English
:
Epoprostenol
Descriptor
Spanish
:
Epoprostenol
Descriptor
Portuguese
:
Epoprostenol
Synonyms
English
:
Prostacyclin
Prostaglandin I2
PGI2
PGX
Tree Number:
D10.251.355.255.100.637.550.500
D10.251.355.255.550.550.500
D23.469.050.175.725.895.500
Definition
English
:
A prostaglandin that is a powerful vasodilator and inhibits
platelet aggregation
. It is biosynthesized enzymatically from
PROSTAGLANDIN ENDOPEROXIDES
in human vascular tissue. The
sodium
salt has been also used to treat primary pulmonary
hypertension
(HYPERTENSION, PULMONARY).
Indexing Annotation
English
:
/chem syn permitted: do not convert to
PROSTAGLANDINS
, SYNTHETIC; DF: PGX
Pharmacological Action:
Antihypertensive Agents
Platelet Aggregation Inhibitors
History Note
English
:
91(78); was PROSTAGLANDINS X 1978-90 (see under PROSTAGLANDINS 1978-83); PROSTACYCLIN was PROSTACYCLINS 1978-93; PROSTAGLANDIN I2 was PROSTAGLANDINS I2 1982-93; PROSTAGLANDIN X was PROSTAGLANDINS X 1991-93
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
29280
Unique Identifier:
D011464
Occurrence in VHL
:
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