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LEUKOTRIENES
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DeCS
Descriptor
English
:
Leukotrienes
Descriptor
Spanish
:
Leucotrienos
Descriptor
Portuguese
:
Leucotrienos
Tree Number:
D10.251.355.255.100.450
D23.469.050.175.450
Definition
English
:
A
family
of biologically active compounds derived from
arachidonic acid
by oxidative
metabolism
through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate
hypersensitivity
and
inflammation
. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and
central nervous system
as well as the
gastrointestinal tract
and the
immune system.
Indexing Annotation
English
:
eicosanoids; GEN or unspecified; prefer specifics; /biosyn /physiol permitted
Entry Combination - descr/qualif
English
:
Leukotrienes
/
antagonists & inhibitors
use
Leukotriene Antagonists
See Related
English
:
Receptors, Leukotriene
History Note
English
:
89
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
28158
Unique Identifier:
D015289
Occurrence in VHL
:
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