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DeCS
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Descriptor English:
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Dideoxyadenosine
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Descriptor Spanish:
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Didesoxiadenosina
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Descriptor Portuguese:
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Didesoxiadenosina
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Synonyms English:
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ddA (Antiviral)
2',3'-Dideoxyadenosine
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Tree Number:
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D03.438.759.590.138.325.105
D13.570.230.229.105
D13.570.230.500.105
D13.570.583.138.325.105
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Definition English:
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. |
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Indexing Annotation English:
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an antiviral; inhibits HIV replication
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Pharmacological Action:
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Antimetabolites
Antiviral Agents
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History Note English:
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90
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Allowable Qualifiers English:
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Record Number:
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24602
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Unique Identifier:
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D016048
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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