Search on:
2',3'-DIDEOXYINOSINE
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Didanosine
Descriptor
Spanish
:
Didanosina
Descriptor
Portuguese
:
Didanosina
Synonyms
English
:
ddI (Antiviral)
2',3'-Dideoxyinosine
Dideoxyinosine
Tree Number:
D03.438.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
Definition
English
:
A dideoxynucleoside compound in which the 3'-hydroxy group on the
sugar
moiety has been replaced by a
hydrogen
. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains.
Didanosine
is a potent inhibitor of
HIV
replication, acting as a chain-terminator of viral
DNA
by binding to reverse transcriptase; ddI is then metabolized to
dideoxyadenosine
triphosphate, its putative active metabolite.
Pharmacological Action:
Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
History Note
English
:
92; was DIDEOXYINOSINE 1990-91
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
30328
Unique Identifier:
D016049
Occurrence in VHL
:
Similar:
DeCS
SciELO
LILACS
LIS