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2',3'-DIDEOXYNUCLEOSIDES
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DeCS
Descriptor
English
:
Dideoxynucleosides
Descriptor
Spanish
:
Didesoxinucleósidos
Descriptor
Portuguese
:
Didesoxinucleosídeos
Synonyms
English
:
Dideoxyribonucleosides
2',3'-Dideoxynucleosides
Tree Number:
D13.570.230.500
Definition
English
:
Nucleosides that have two hydroxy groups removed from the
sugar
moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as
antimetabolites
. The
nucleosides
are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral
reverse transcription.
Indexing Annotation
English
:
antivirals &
antimetabolites
Pharmacological Action:
Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
History Note
English
:
89
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
23607
Unique Identifier:
D015224
Occurrence in VHL
:
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