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3-IODOBENZYLGUANIDINE
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DeCS
Descriptor
English
:
3-Iodobenzylguanidine
Descriptor
Spanish
:
3-Yodobencilguanidina
Descriptor
Portuguese
:
3-Iodobenzilguanidina
Synonyms
English
:
(3-Iodo-(131I)benzyl)guanidine
Iobenguane
MIBG
Tree Number:
D02.078.370.510
D02.455.426.559.389.454.300
D02.455.526.581.496.300
Definition
English
:
A
guanidine
analog with specific affinity for
tissues
of the
sympathetic nervous system
and related tumors. The radiolabeled
forms
are used as
antineoplastic agents
and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the
adrenal medulla
and also inhibits ADP-ribosyltransferase.
Pharmacological Action:
Antineoplastic Agents
Enzyme Inhibitors
Radiopharmaceuticals
History Note
English
:
98; use 3-IODOBENZYLGUANIDINE (NM) 1980-97
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
33386
Unique Identifier:
D019797
Occurrence in VHL
:
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