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MEGLUTOL
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DeCS
Descriptor
English
:
Meglutol
Descriptor
Spanish
:
Meglutol
Descriptor
Portuguese
:
Meglutol
Synonyms
English
:
3-Hydroxy-3-methylglutaric Acid
Tree Number:
D02.241.081.337.351.550
Definition
English
:
An antilipemic agent which lowers
cholesterol
,
triglycerides
,
serum
beta-lipoproteins and
phospholipids
. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl
coenzyme A
as well as inhibiting the activity of
HYDROXYMETHYLGLUTARYL COA REDUCTASES
which is the rate limiting enzyme in the biosynthesis of
cholesterol.
Pharmacological Action:
Anticholesteremic Agents
Antilipemic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
History Note
English
:
96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
7073
Unique Identifier:
D015093
Occurrence in VHL
:
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