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PENTOSTATIN
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DeCS
Descriptor
English
:
Pentostatin
Descriptor
Spanish
:
Pentostatina
Descriptor
Portuguese
:
Pentostatina
Synonyms
English
:
2'-Deoxycoformycin
Tree Number:
D03.383.742.680.350.200.700
D13.570.230.677
D13.570.685.350.200.700
Definition
English
:
A potent inhibitor of
ADENOSINE DEAMINASE
. The drug induces
APOPTOSIS
of
LYMPHOCYTES
, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL
LEUKEMIA
. It is also synergistic with some other
antineoplastic agents
and has immunosuppressive activity.
Pharmacological Action:
Antineoplastic Agents
Enzyme Inhibitors
History Note
English
:
90; for CO-VIDARABINE use PENTOSTATIN 1982-97
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
24830
Unique Identifier:
D015649
Occurrence in VHL
:
Similar:
DeCS
SciELO
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