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DeCS
Descriptor
English
:
Cytochrome P-450 CYP2B1
Descriptor
Spanish
:
Citocromo P-450 CYP2B1
Descriptor
Portuguese
:
Citocromo P-450 CYP2B1
Synonyms
English
:
Benzyloxyresorufin O-Dealkylase
BROD
CYP2B1
Pentoxyresorufin O-Dealkylase
PROD
Tree Number:
D08.244.453.040.888
D08.811.682.690.708.170.040.499
D12.776.422.220.453.040.777
Definition
English
:
A major cytochrome P-450 enzyme which is inducible by
PHENOBARBITAL
in both the
LIVER
and SMALL INTESTINE. It is active in the
metabolism
of compounds like pentoxyresorufin,
TESTOSTERONE
, and
ANDROSTENEDIONE
. This enzyme, encoded by CYP2B1 gene, also mediates the activation of
CYCLOPHOSPHAMIDE
and
IFOSFAMIDE
to
MUTAGENS.
Indexing Annotation
English
:
do not confuse with other cytochrome P-450 CYP's
History Note
English
:
97; was PENTOXYRESORUFIN O-DEALKYLASE (NM) 1985-96
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
33010
Unique Identifier:
D019362
Occurrence in VHL
:
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