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BROMODEOXYURIDINE
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DeCS
Descriptor
English
:
Bromodeoxyuridine
Descriptor
Spanish
:
Bromodesoxiuridina
Descriptor
Portuguese
:
Bromodesoxiuridina
Synonyms
English
:
Bromouracil Deoxyriboside
Broxuridine
BUdR
BrdU
Tree Number:
D03.383.742.680.852.300.150
D13.570.230.430.196
D13.570.685.852.300.150
Definition
English
:
A nucleoside that substitutes for
thymidine
in
DNA
and thus acts as an antimetabolite. It causes breaks in
chromosomes
and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary
brain
tumors.
Pharmacological Action:
Antimetabolites
Antimetabolites, Antineoplastic
Antiviral Agents
Radiation-Sensitizing Agents
History Note
English
:
66(65)
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
2002
Unique Identifier:
D001973
Occurrence in VHL
:
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