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BUPRENORPHINE
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DeCS
Descriptor
English
:
Buprenorphine
Descriptor
Spanish
:
Buprenorfina
Descriptor
Portuguese
:
Buprenorfina
Tree Number:
D03.132.577.249.150
D03.549.686.150
D03.605.497.150
D04.615.723.795.150
Definition
English
:
A derivative of the opioid alkaloid
THEBAINE
that is a more potent and longer lasting analgesic than
MORPHINE
. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at
delta
receptors. The lack of delta-agonist activity has been suggested to account for the
observation
that
buprenorphine
tolerance may not develop with chronic use.
Pharmacological Action:
Analgesics, Opioid
Narcotic Antagonists
Narcotics
History Note
English
:
87(79); was see under MORPHINANS 1979-86
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
2079
Unique Identifier:
D002047
Occurrence in VHL
:
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