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BUTHIONINE SULFOXIMINE
Descriptors Found:
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DeCS
Descriptor
English
:
Buthionine Sulfoximine
Descriptor
Spanish
:
Butionina Sulfoximina
Descriptor
Portuguese
:
Butionina Sulfoximina
Tree Number:
D02.886.030.676.620.125
D12.125.166.676.620.125
Definition
English
:
A synthetic amino acid that depletes
glutathione
by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in
glutathione
biosynthesis. It has been shown to inhibit the proliferative response in human
T-lymphocytes
and inhibit
macrophage activation
. (J Biol Chem 1995;270(33):1945-7)
Pharmacological Action:
Antimetabolites
Antimetabolites, Antineoplastic
Enzyme Inhibitors
Radiation-Protective Agents
Radiation-Sensitizing Agents
History Note
English
:
97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
33034
Unique Identifier:
D019328
Occurrence in VHL
:
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