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Descriptor English:   Chloramphenicol O-Acetyltransferase 
Descriptor Spanish:   Cloranfenicol O-Acetiltransferasa 
Descriptor Portuguese:   Cloranfenicol O-Acetiltransferase 
Synonyms English:   CAT Enzyme
Chloramphenicol Acetyltransferase  
Tree Number:   D08.811.913.050.134.170
Definition English:   An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28. 
See Related English:   Chloramphenicol Resistance
 
History Note English:   98(89) 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   23584 
Unique Identifier:   D015500 

Occurrence in VHL:
 

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