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CD118 ANTIGENS
Descriptors Found:
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DeCS
Descriptor
English
:
Leukemia Inhibitory Factor Receptor alpha Subunit
Descriptor
Spanish
:
Subunidad alfa del Receptor del Factor Inhibidor de Leucemia
Descriptor
Portuguese
:
Subunidade alfa de Receptor de Fator Inibidor de Leucemia
Synonyms
English
:
Antigens, CD118
CD118 Antigens
Tree Number:
D12.776.543.750.705.852.500.750
D12.776.543.750.705.852.555.800.750
D12.776.543.750.750.400.550.250.750
D23.050.301.264.035.493
D23.101.100.110.493
Definition
English
:
A receptor subunit that combines with
CYTOKINE RECEPTOR GP130
to form the dual specificity receptor for
LEUKEMIA INHIBITORY FACTOR
and
ONCOSTATIN M
. The subunit is also a component of the
CILIARY NEUROTROPHIC FACTOR
RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to
ALTERNATIVE SPLICING
of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
History Note
English
:
2007
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52379
Unique Identifier:
D053680
Occurrence in VHL
:
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