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CD40 ANTIGENS
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DeCS
Descriptor
English
:
Antigens, CD40
Descriptor
Spanish
:
Antígenos CD40
Descriptor
Portuguese
:
Antígenos CD40
Synonyms
English
:
CD40 Antigens
Tumor Necrosis Factor Receptor Superfamily, Member 5
Tree Number:
D12.776.543.750.705.852.760.097
D23.050.301.264.035.140
D23.050.301.264.051.140
D23.101.100.110.140
D23.101.100.150.140
Definition
English
:
A member of the tumor
necrosis
factor receptor superfamily with specificity for
CD40 LIGAND
. It is found on mature
B-LYMPHOCYTES
and some
EPITHELIAL CELLS
, lymphoid
DENDRITIC CELLS
. Evidence suggests that CD40-dependent activation of B-cells is important for generation of
memory
B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in
HYPER-IGM IMMUNODEFICIENCY SYNDROME
, TYPE 3. Signaling of the receptor occurs through its
association
with TNF RECEPTOR-ASSOCIATED FACTORS.
See Related
English
:
CD40 Ligand
History Note
English
:
96; was CD40 ANTIGEN (NM) 1989-95 & CDW40 ANTIGEN (NM) 1988-95
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
32846
Unique Identifier:
D019013
Occurrence in VHL
:
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