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CD45RA ANTIGENS
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DeCS
Descriptor
English
:
Antigens, CD45
Descriptor
Spanish
:
Antígenos CD45
Descriptor
Portuguese
:
Antígenos CD45
Synonyms
English
:
CD45 Antigens
CD45R Antigens
CD45RA Antigens
CD45RO Antigens
Leukocyte Common Antigens
Protein Tyrosine Phosphatase, Receptor Type, C
Tree Number:
D08.811.277.352.650.775.400.100.500
D12.644.360.587.100.500
D12.776.476.592.100.500
D12.776.543.733.937.500
D23.050.301.264.035.145
D23.101.100.110.145
Definition
English
:
High-molecular weight
glycoproteins
uniquely expressed on the surface of
LEUKOCYTES
and their hemopoietic progenitors. They contain a cytoplasmic protein
tyrosine
phosphatase activity which plays a
role
in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45
antigens
occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three
exons
.
History Note
English
:
93; was CD45 ANTIGEN (NM) 1984-92; RT7 ANTIGEN was RT7 (SY) to HISTOCOMPATIBILITY ANTIGENS RT (NM); B220 ANTIGEN was NM 1990-95
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
30830
Unique Identifier:
D017493
Occurrence in VHL
:
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