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CIP-KIP CYCLIN-DEPENDENT KINASE INHIBITORS
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor Proteins
Descriptor
Spanish
:
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
Descriptor
Portuguese
:
Proteínas Inibidoras de Quinase Dependente de Ciclina
Synonyms
English
:
CIP-KIP Cyclin-Dependent Kinase Inhibitors
INK4 Cyclin-Dependent Kinase Inhibitors
Tree Number:
D12.644.360.225
D12.776.167.187
D12.776.476.225
D12.776.624.776.355
Definition
English
:
A group of
cell cycle proteins
that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit
CELL CYCLE
progression and help
control
CELL PROLIFERATION
following GENOTOXIC
STRESS
as well as during
CELL DIFFERENTIATION.
Pharmacological Action:
Protein Kinase Inhibitors
History Note
English
:
2006
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50927
Unique Identifier:
D050756
Occurrence in VHL
:
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