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CYP11B2
Descriptors Found:
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DeCS
Descriptor
English
:
Aldosterone Synthase
Descriptor
Spanish
:
Aldosterona Sintasa
Descriptor
Portuguese
:
Aldosterona Sintase
Synonyms
English
:
CYP11B2
Cytochrome P-450 CYP11B2
Steroid 18-Hydroxylase
Tree Number:
D08.244.453.915.050
D08.811.682.690.708.170.915.050
D08.811.682.690.708.783.050
D12.776.422.220.453.915.050
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of
steroids
in the presence of molecular
oxygen
and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of
CORTICOSTERONE
to
18-hydroxycorticosterone
and the subsequent conversion to
ALDOSTERONE.
Indexing Annotation
English
:
do not confuse with other cytochrome P-450 CYP's
History Note
English
:
2003 (1979)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
33013
Unique Identifier:
D019405
Occurrence in VHL
:
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