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CYP7
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DeCS
Descriptor
English
:
Cholesterol 7-alpha-Hydroxylase
Descriptor
Spanish
:
Colesterol 7-alfa-Hidroxilasa
Descriptor
Portuguese
:
Colesterol 7-alfa-Hidroxilase
Synonyms
English
:
CYP7
CYP7A
Cytochrome P-450 CYP7
Tree Number:
D08.244.453.915.200
D08.811.682.690.708.170.915.200
D08.811.682.690.708.783.200
D12.776.422.220.453.915.200
Definition
English
:
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of
CHOLESTEROL
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP7, converts
cholesterol
to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of
BILE
ACIDS.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23193
Unique Identifier:
D002790
Occurrence in VHL
:
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