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CALRETICULIN
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DeCS
Descriptor
English
:
Calreticulin
Descriptor
Spanish
:
Calreticulina
Descriptor
Portuguese
:
Calreticulina
Tree Number:
D12.644.360.381.374
D12.776.157.125.412.374
D12.776.476.387.374
D12.776.503.303
Definition
English
:
A multifunctional protein that is found primarily within membrane-bound
organelles
. In the
ENDOPLASMIC RETICULUM
it binds to specific N-linked
oligosaccharides
found on newly-synthesized
proteins
and functions as a MOLECULAR CHAPERONE that may play a
role
in
PROTEIN FOLDING
or retention and degradation of misfolded
proteins
. In addition
calreticulin
is a major storage form for
CALCIUM
and functions as a calcium-signaling molecule that can regulate intracellular
calcium
HOMEOSTASIS.
History Note
English
:
2003; use CALRETICULIN (NM) 1990-2002
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
37386
Unique Identifier:
D037282
Occurrence in VHL
:
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DeCS
SciELO
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