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CASPASES
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DeCS
Descriptor
English
:
Caspases
Descriptor
Spanish
:
Caspasas
Descriptor
Portuguese
:
Caspases
Tree Number:
D08.811.277.656.300.215.126
D12.644.360.075.405
D12.776.476.075.405
Definition
English
:
A
family
of intracellular
CYSTEINE ENDOPEPTIDASES
that play a
role
in regulating
INFLAMMATION
and
APOPTOSIS
. They specifically cleave
peptides
at a
CYSTEINE
amino acid that follows an
ASPARTIC ACID
residue.
Caspases
are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of
caspases
, sequential activation of precursors by activated
caspases
can occur.
Indexing Annotation
English
:
CASPASES, EFFECTOR and
CASPASES
, INITIATOR and specifics are available
See Related
English
:
Apoptosis
History Note
English
:
99
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
33826
Unique Identifier:
D020169
Occurrence in VHL
:
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