Search on: CELL SURFACE RECEPTORS 
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Descriptor English:   Receptors, Cell Surface 
Descriptor Spanish:   Receptores de Superficie Celular 
Descriptor Portuguese:   Receptores da Superfície Celular 
Synonyms English:   Cell Surface Receptors
Receptors, Endogenous Substances
Hormone Receptors, Cell Surface  
Tree Number:   D12.776.543.750
Definition English:   Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. 
Indexing Annotation English:   GEN: prefer specifics; coord IM with specific endogenous substance (IM); for hormone receptors in general coord HORMONES (IM) + RECEPTORS, CELL SURFACE (IM) or RECEPTORS, CYTOPLASMIC AND NUCLEAR (IM), for receptors of specific hormones, coord specific hormone or hormone group (IM) + precoord hormone receptor (e.g., RECEPTORS, ALDOSTERONE) (IM) or precoord hormone-group receptor (e.g., RECEPTORS, GLUCOCORTICOID) (IM); DF: RECEPT CELL SURFACE
History Note English:   94; was RECEPTORS, ENDOGENOUS SUBSTANCES 1983-93; was RECEPTORS, HORMONE 1973-82; CELL RECEPTORS & RECEPTORS, BIOLOGIC were see RECEPTORS, ENDOGENOUS SUBSTANCES 1985-93; HORMONE RECEPTORS was see RECEPTORS, ENDOGENOUS SUBSTANCES 1975-93 
Allowable Qualifiers English:  
administration & dosage agonists
antagonists & inhibitors analysis
biosynthesis blood
chemistry classification
drug effects deficiency
genetics history
immunology isolation & purification
metabolism physiology
radiation effects therapeutic use
ultrastructure  
Record Number:   31906 
Unique Identifier:   D011956 

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