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CELL-MEDIATED LYMPHOLYTIC CELLS
Descriptors Found:
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DeCS
Descriptor
English
:
T-Lymphocytes, Cytotoxic
Descriptor
Spanish
:
Linfocitos T Citotóxicos
Descriptor
Portuguese
:
Linfócitos T Citotóxicos
Synonyms
English
:
Cell-Mediated Lympholytic Cells
Cytotoxic T-Lymphocytes
TC1 Cells
TC2 Cells
Tree Number:
A11.118.637.555.567.569.220.200
A15.145.229.637.555.567.569.220.200
A15.382.490.555.567.569.220.200
Definition
English
:
Immunized
T-lymphocytes
which can directly destroy appropriate target
cells
. These cytotoxic
lymphocytes
may be generated
in vitro
in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after
immunization
with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive
cells
are distinct from natural
killer cells
(KILLER
CELLS
, NATURAL) and from
KILLER CELLS
mediating
antibody-dependent cell cytotoxicity
. There are two effector phenotypes: TC1 and TC2.
Indexing Annotation
English
:
subpopulations: coord IM with
T-LYMPHOCYTE SUBSETS
(IM)
History Note
English
:
90; was T LYMPHOCYTES, CYTOTOXIC 1983-89
Allowable Qualifiers
English
:
chemistry
classification
cytology
drug effects
enzymology
immunology
metabolism
microbiology
pathology
physiology
parasitology
radiography
radiation effects
radionuclide imaging
secretion
transplantation
ultrastructure
ultrasonography
virology
Record Number:
23531
Unique Identifier:
D013602
Occurrence in VHL
:
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