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CHEMOKINE CXCL4
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DeCS
Descriptor
English
:
Platelet Factor 4
Descriptor
Spanish
:
Factor Plaquetario 4
Descriptor
Portuguese
:
Fator Plaquetário 4
Synonyms
English
:
Antiheparin Factor
CXCL4 Chemokine
Chemokine CXCL4
Tree Number:
D12.644.276.374.200.120.900
D12.776.124.125.720
D12.776.467.374.200.120.900
D23.119.940
D23.125.300.120.900
D23.469.200.120.900
D23.529.374.200.120.900
Definition
English
:
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution.
Platelet factor 4
has a high affinity for
HEPARIN
and is often found complexed with
GLYCOPROTEINS
such as
PROTEIN C
.
Pharmacological Action:
Coagulants
History Note
English
:
84(76); was see under BLOOD COAGULATION FACTORS 1976-83
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22259
Unique Identifier:
D010978
Occurrence in VHL
:
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