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DeCS
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Descriptor English:
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Cholera Toxin
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Descriptor Spanish:
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Toxina del Cólera
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Descriptor Portuguese:
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Toxina da Cólera
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Synonyms English:
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Cholera Toxin Protomer A
Cholera Toxin Protomer B
Choleragen
Choleragenoid
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Tree Number:
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D08.811.913.400.725.115.180
D23.946.123.194
D23.946.330.150
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Definition English:
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An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. |
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Indexing Annotation English:
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/antag permitted but consider also ANTITOXINS
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Pharmacological Action:
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Adjuvants, Immunologic
Poisons
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History Note English:
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78
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Allowable Qualifiers English:
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Record Number:
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2822
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Unique Identifier:
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D002772
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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