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CHOLESTEROL DESMOLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cholesterol Side-Chain Cleavage Enzyme
Descriptor
Spanish
:
Enzima de Desdoblamiento de la Cadena Lateral del Colesterol
Descriptor
Portuguese
:
Enzima de Clivagem da Cadeia Lateral do Colesterol
Synonyms
English
:
CYP11A1
Cholesterol Desmolase
Cholesterol Monooxygenase (Side-Chain-Cleaving)
Cytochrome P-450 CYP11A1
Cytochrome P-450(scc)
Tree Number:
D08.244.453.915.212
D08.811.600.200
D08.811.682.690.708.170.915.212
D08.811.682.690.708.783.212
D12.776.422.220.453.915.212
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27
cholesterol
to C21
pregnenolone
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid
hormones.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23192
Unique Identifier:
D002786
Occurrence in VHL
:
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