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CIMETIDINE
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DeCS
Descriptor
English
:
Cimetidine
Descriptor
Spanish
:
Cimetidina
Descriptor
Portuguese
:
Cimetidina
Tree Number:
D02.078.370.200
D03.383.129.308.130
Definition
English
:
A
histamine
congener, it competitively inhibits
HISTAMINE
binding to
HISTAMINE
H2 RECEPTORS.
Cimetidine
has a range of pharmacological actions. It inhibits
GASTRIC ACID
secretion, as well as PEPSIN and
GASTRINS
output. It also blocks the activity of CYTOCHROME P-450 which might explain proposals for use in
NEOADJUVANT THERAPY.
Pharmacological Action:
Anti-Ulcer Agents
Enzyme Inhibitors
Histamine H2 Antagonists
History Note
English
:
84(78); was see under GUANIDINES 1978-83
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
2953
Unique Identifier:
D002927
Occurrence in VHL
:
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