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CLARITHROMYCIN
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DeCS
Descriptor
English
:
Clarithromycin
Descriptor
Spanish
:
Claritromicina
Descriptor
Portuguese
:
Claritromicina
Tree Number:
D02.540.505.250.100
D04.345.349.250.100
D09.408.477.250.100
Definition
English
:
A semisynthetic macrolide antibiotic derived from
ERYTHROMYCIN
that is active against a variety of microorganisms. It can inhibit protein synthesis in
bacteria
by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Pharmacological Action:
Anti-Bacterial Agents
Protein Synthesis Inhibitors
History Note
English
:
93; was CLARITHROMYCIN (NM) 1987-92
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
30785
Unique Identifier:
D017291
Occurrence in VHL
:
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