|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Histocompatibility Antigens Class II
|
|
Descriptor Spanish:
|
|
Antígenos Clase II de Histocompatibilidad
|
|
Descriptor Portuguese:
|
|
Antígenos de Histocompatibilidade Classe II
|
|
Synonyms English:
|
|
Antigens, Immune Response
Class II Antigens
Ia Antigens
IA-like Antigens
Immune-Associated Antigens
Immune Response Antigens
Immune-Response-Associated Antigens
|
|
Tree Number:
|
|
D23.050.301.500.410
D23.050.705.552.410
|
|
Definition English:
|
|
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen. |
|
Indexing Annotation English:
|
|
human & animal; GEN: prefer specifics; see also HLA ANTIGENS & specifics for human; X ref IA ANTIGENS refers to any class II histocompatibility antigen
|
|
History Note English:
|
|
89; was ANTIGENS, IMMUNE RESPONSE 1981-88; I-A-ANTIGEN was NM 1987-93
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
24381
|
|
Unique Identifier:
|
|
D000949
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS SciELO LILACS LIS
|