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DeCS
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Descriptor English:
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Tetanus Toxin
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Descriptor Spanish:
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Toxina Tetánica
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Descriptor Portuguese:
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Toxina Tetânica
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Synonyms English:
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Clostridial Neurotoxin
Clostridium tetani Toxin
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Tree Number:
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D12.776.097.872
D23.946.123.893
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Definition English:
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Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS. |
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Indexing Annotation English:
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/antag permitted but consider also TETANUS ANTITOXIN
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Pharmacological Action:
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Neurotoxins
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See Related English:
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Tetanus Antitoxin
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History Note English:
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65
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Allowable Qualifiers English:
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Record Number:
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14124
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Unique Identifier:
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D013744
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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