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COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS
Descriptors Found:
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DeCS
Descriptor
English
:
Colorectal Neoplasms, Hereditary Nonpolyposis
Descriptor
Spanish
:
Neoplasias Colorrectales Hereditarias sin Poliposis
Descriptor
Portuguese
:
Neoplasias Colorretais Hereditárias sem Polipose
Synonyms
English
:
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Syndrome
Tree Number:
C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255
Definition
English
:
A group of autosomal-dominant inherited diseases in which
COLON
CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of
polyps
, hereditary nonpolyposis
colorectal neoplasms
occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR)
genes.
Indexing Annotation
English
:
DF: HNPCC
History Note
English
:
87
Allowable Qualifiers
English
:
blood
blood supply
cerebrospinal fluid
chemistry
chemically induced
classification
complications
diet therapy
diagnosis
drug therapy
economics
ethnology
embryology
enzymology
epidemiology
etiology
genetics
history
immunology
metabolism
microbiology
mortality
nursing
pathology
prevention & control
physiopathology
parasitology
psychology
radiography
rehabilitation
radionuclide imaging
radiotherapy
secondary
secretion
surgery
therapy
ultrastructure
urine
ultrasonography
veterinary
virology
Record Number:
24009
Unique Identifier:
D003123
Occurrence in VHL
:
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