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COMPLEMENTARITY DETERMINING REGIONS
Descriptors Found:
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DeCS
Descriptor
English
:
Complementarity Determining Regions
Descriptor
Spanish
:
Regiones Determinantes de Complementariedad
Descriptor
Portuguese
:
Regiões Determinantes de Complementaridade
Synonyms
English
:
Hypervariable Regions
Tree Number:
D12.776.124.486.485.114.345.180
D12.776.124.486.485.680.650.500.180
D12.776.124.486.485.797.180
D12.776.124.790.651.114.345.180
D12.776.124.790.651.680.650.500.180
D12.776.124.790.651.797.180
D12.776.377.715.548.114.345.180
D12.776.377.715.548.680.650.500.180
D12.776.377.715.548.797.180
D12.776.543.750.705.816.824.300
G06.184.603.060.425.160
Definition
English
:
Three regions (CDR1; CDR2 and CDR3) of
amino acid sequence
in the
IMMUNOGLOBULIN VARIABLE REGION
that are highly divergent. Together the CDRs from the
light
and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Pharmacological Action:
Immunologic Factors
See Related
English
:
Receptors, Antigen, T-Cell
History Note
English
:
2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION use IMMUNOGLOBULIN VARIABLE REGION 1988-2000
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
35339
Unique Identifier:
D022801
Occurrence in VHL
:
Similar:
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SciELO
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