Search on: CRYSTALLINS, ALPHA 
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Descriptor English:   alpha-Crystallins 
Descriptor Spanish:   alfa-Cristalinas 
Descriptor Portuguese:   alfa-Cristalinas 
Synonyms English:   Crystallins, alpha  
Tree Number:   D12.776.306.366.100
D12.776.580.157
Definition English:   A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. 
History Note English:   2003; for ALPHA-CRYSTALLIN use CRYSTALLINS 1982-2002 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   37439 
Unique Identifier:   D038201 

Occurrence in VHL: 		 

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