Search on: CYCLIN-DEPENDENT KINASE INHIBITOR P27 
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Descriptor English:   Cyclin-Dependent Kinase Inhibitor p27 
Descriptor Spanish:   Inhibidor p27 de las Quinasas Dependientes de la Ciclina 
Descriptor Portuguese:   Inibidor de Quinase Dependente de Ciclina p27 
Tree Number:   D12.644.360.225.600
D12.776.167.187.600
D12.776.476.225.600
D12.776.624.776.355.600
Definition English:   A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2. 
Pharmacological Action:   Protein Kinase Inhibitors
 
History Note English:   2006(1992) 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   50932 
Unique Identifier:   D050760 

Occurrence in VHL: 		 

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