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CYTOCHROME P-450 CYP21
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 21-Hydroxylase
Descriptor
Spanish
:
Esteroide 21-Hidroxilasa
Descriptor
Portuguese
:
Esteróide 21-Hidroxilase
Synonyms
English
:
Cytochrome P-450 CYP21
Steroid 21-Monooxygenase
Tree Number:
D08.244.453.915.760
D08.811.682.690.708.170.915.760
D08.811.682.690.708.783.760
D12.776.422.220.453.915.760
Definition
English
:
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid
hormones
(CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 21-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23465
Unique Identifier:
D013255
Occurrence in VHL
:
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