Search on: DNA RESTRICTION-MODIFICATION ENZYMES 
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Descriptor English:   DNA Restriction-Modification Enzymes 
Descriptor Spanish:   Enzimas de Restricción-Modificación del ADN 
Descriptor Portuguese:   Enzimas de Restrição-Modificação do DNA 
Synonyms English:   Restriction-Modification Systems  
Tree Number:   D08.811.150
Definition English:   Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage. 
Indexing Annotation English:   DF: RESTRICT MOD ENZYMES
History Note English:   89 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   23619 
Unique Identifier:   D015280 

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