Search on: DNA TOPOISOMERASE (ATP-HYDROLYSING) 
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Descriptor English:   DNA Topoisomerases, Type II 
Descriptor Spanish:   Topoisomerasas de ADN Tipo II 
Descriptor Portuguese:   DNA Topoisomerases Tipo II 
Synonyms English:   DNA Topoisomerase II
DNA Topoisomerase (ATP-Hydrolysing)  
Tree Number:   D08.811.399.403.741
Definition English:   DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. 
Indexing Annotation English:   GEN or unspecified; prefer specifics
History Note English:   2002; use DNA TOPOISOMERASE (ATP-HYDROLYSING) 1994-2001, use DNA GYRASE 1980-1993 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   31731 
Unique Identifier:   D004250 

Occurrence in VHL:
 

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