Search on: DNA TOPOISOMERASE II, BACTERIAL 
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Descriptor English:   DNA Topoisomerases, Type II, Bacterial 
Descriptor Spanish:   Topoisomerasas de ADN Tipo II Bacterianas 
Descriptor Portuguese:   DNA Topoisomerases Tipo II Bacterianas 
Synonyms English:   DNA Topoisomerase II, Bacterial  
Tree Number:   D08.811.399.403.741.300
Definition English:   Bacterial enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA duplex. Bacterial DNA topoisomerases in the Type II class exist as heterotetramers of 2 subunits, such as 2 gyrA and 2 gyrB in DNA GYRASE. 
History Note English:   2002 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   36088 
Unique Identifier:   D027061 

Occurrence in VHL:
 

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