Search on: DNA TOPOISOMERASES, TYPE I 
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Descriptor English:   DNA Topoisomerases, Type I 
Descriptor Spanish:   Topoisomerasas de ADN Tipo I 
Descriptor Portuguese:   DNA Topoisomerases Tipo I 
Synonyms English:   DNA Nicking-Closing Protein
DNA Relaxing Enzyme
DNA Relaxing Protein
DNA Topoisomerase I
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
DNA Topoisomerase  
Tree Number:   D08.811.399.403.483
Definition English:   DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. 
Indexing Annotation English:   GEN or unspecified; prefer specifics; do not confuse X ref DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES
History Note English:   2002; use DNA TOPOISOMERASE 1994-2001, use DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN use DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME use DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME use DNA UNTWISTING ENZYMES 1978-1993; for OMEGA PROTEIN use OMEGA PROTEINS 1978-1993 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   31732 
Unique Identifier:   D004264 

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