Search on: DNA TOPOISOMERASES, TYPE II, ARCHAEAL 
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Descriptor English:   DNA Topoisomerases, Type II, Archaeal 
Descriptor Spanish:   Topoisomerasas de ADN Tipo II Arqueales 
Descriptor Portuguese:   DNA Topoisomerases Tipo II Arqueais 
Tree Number:   D08.811.399.403.741.249
Definition English:   Archaeal enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. 
History Note English:   2002 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   36087 
Unique Identifier:   D027921 

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