Search on: DNA-DEPENDENT DNA POLYMERASE II 
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Descriptor English:   DNA Polymerase II 
Descriptor Spanish:   ADN Polimerasa II 
Descriptor Portuguese:   DNA Polimerase II 
Synonyms English:   DNA-Dependent DNA Polymerase II
Pol II
DNA Polymerase epsilon  
Tree Number:   D08.811.913.696.445.308.300.230
Definition English:   A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7. 
History Note English:   84(77); for DNA POLYMERASE EPSILON use DNA POLYMERASE II (NM) 1994-97 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   4324 
Unique Identifier:   D004257 

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