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DEMETHYL EPIPODOPHYLLOTOXIN ETHYLIDINE GLUCOSIDE
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DeCS
Descriptor
English
:
Etoposide
Descriptor
Spanish
:
Etopósido
Descriptor
Portuguese
:
Etoposídeo
Synonyms
English
:
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Tree Number:
D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
Definition
English
:
A semisynthetic derivative of
PODOPHYLLOTOXIN
that exhibits antitumor activity.
Etoposide
inhibits
DNA
synthesis by forming a complex with topoisomerase II and
DNA
. This complex induces breaks in double stranded
DNA
and prevents repair by topoisomerase II binding. Accumulated breaks in
DNA
prevent entry into the mitotic phase of
cell division
, and
lead
to
cell death
.
Etoposide
acts primarily in the G2 and S phases of the
cell cycle.
Pharmacological Action:
Antineoplastic Agents, Phytogenic
History Note
English
:
87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
5143
Unique Identifier:
D005047
Occurrence in VHL
:
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