Search on: DIMETHYLERGOMETRIN 
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Descriptor English:   Methysergide 
Descriptor Spanish:   Metisergida 
Descriptor Portuguese:   Metissergida 
Synonyms English:   Dimethylergometrin
Methylmethylergonovine  
Tree Number:   D03.132.327.287.689
D03.549.439.689
Definition English:   An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome. 
Pharmacological Action:   Serotonin Antagonists
Vasoconstrictor Agents
 
History Note English:   65(63); METHYSERGIDE DERIVATIVES was see under METHYSERGIDE 1975-77; was see under ERGOLINES 1969-74 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
diagnostic use economics
history immunology
isolation & purification metabolism
pharmacology pharmacokinetics
poisoning radiation effects
supply & distribution standards
toxicity therapeutic use
urine  
Record Number:   8973 
Unique Identifier:   D008784 

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