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DIPHTHERIA TOXIN
Descriptors Found:
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DeCS
Descriptor
English
:
Diphtheria Toxin
Descriptor
Spanish
:
Toxina Diftérica
Descriptor
Portuguese
:
Toxina Diftérica
Synonyms
English
:
Corynebacterium Diphtheriae Toxin
Tree Number:
D08.811.913.400.725.115.220
D23.946.123.305
Definition
English
:
An ADP-ribosylating polypeptide produced by
CORYNEBACTERIUM DIPHTHERIAE
that causes the
signs and symptoms
of
DIPHTHERIA
. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE)
TRANSFERASES
which transfers ADP
RIBOSE
to
PEPTIDE ELONGATION FACTOR 2
thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into
cells
.
Indexing Annotation
English
:
/antag permitted but consider also
DIPHTHERIA ANTITOXIN
Pharmacological Action:
Poisons
See Related
English
:
Diphtheria Toxoid
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
4224
Unique Identifier:
D004167
Occurrence in VHL
:
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