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DeCS
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Descriptor English:
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Disintegrins
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Descriptor Spanish:
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Desintegrinas
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Descriptor Portuguese:
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Disintegrinas
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Tree Number:
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D12.644.138
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Definition English:
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A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. |
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Indexing Annotation English:
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polypeptides from snake venom; platelet aggregation inhib
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Pharmacological Action:
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Platelet Aggregation Inhibitors
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History Note English:
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97; was DISINTEGRINS (NM) 1992-96
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Allowable Qualifiers English:
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Record Number:
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33035
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Unique Identifier:
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D019483
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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