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DOPAMINERGIC ANTAGONISTS
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DeCS
Descriptor
English
:
Dopamine Antagonists
Descriptor
Spanish
:
Antagonistas de Dopamina
Descriptor
Portuguese
:
Antagonistas de Dopamina
Synonyms
English
:
Dopamine Receptor Antagonists
Dopaminergic Antagonists
Tree Number:
D27.505.519.625.150.175
D27.505.696.577.150.175
Definition
English
:
Drugs that bind to but do not activate
DOPAMINE
RECEPTORS, thereby blocking the actions of
dopamine
or exogenous agonists. Many drugs used in the treatment of
psychotic disorders
(ANTIPSYCHOTIC AGENTS) are
dopamine antagonists
, although their therapeutic effects may be due to long-term adjustments of the
brain
rather than to the acute effects of blocking
dopamine
receptors.
Dopamine antagonists
have been used for several other clinical purposes including as
ANTIEMETICS
, in the treatment of
Tourette syndrome
, and for
hiccup
.
Dopamine
receptor blockade is associated with
NEUROLEPTIC MALIGNANT SYNDROME
.
Indexing Annotation
English
:
DF:
DOPAMINE
ANTAG
History Note
English
:
95
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
32275
Unique Identifier:
D018492
Occurrence in VHL
:
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