Search on: E2F TRANSCRIPTION FACTORS 
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Descriptor English:   E2F Transcription Factors 
Descriptor Spanish:   Factores de Transcripción E2F 
Descriptor Portuguese:   Fatores de Transcrição E2F 
Tree Number:   D12.776.930.311
Definition English:   A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation. 
History Note English:   2006(1991) 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   51180 
Unique Identifier:   D050684 

Occurrence in VHL: 		 

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