Search on: EFLORNITHINE 
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Descriptor English:   Eflornithine 
Descriptor Spanish:   Eflornitina 
Descriptor Portuguese:   Eflornitina 
Synonyms English:   alpha-Difluoromethylornithine
Difluoromethylornithine  
Tree Number:   D12.125.068.665.340
D12.125.095.765.340
Definition English:   An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway. 
Indexing Annotation English:   DF:DFMO
Pharmacological Action:   Antineoplastic Agents
Enzyme Inhibitors
Trypanocidal Agents
 
History Note English:   91; was ALPHA-DIFLUOROMETHYLORNITHINE 1987-90 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
diagnostic use economics
history immunology
isolation & purification metabolism
pharmacology pharmacokinetics
poisoning radiation effects
supply & distribution standards
toxicity therapeutic use
urine  
Record Number:   29232 
Unique Identifier:   D000518 

Occurrence in VHL: 		 

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