Search on: GLOBOSIDES 
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Descriptor English:   Globosides 
Descriptor Spanish:   Globósidos 
Descriptor Portuguese:   Globosídeos 
Synonyms English:   Cytolipins
Lacto-N-neotetraosylceramide
Lacto-N-tetraosylceramide  
Tree Number:   D02.065.313.425
D09.400.410.420.525.200.425
D10.390.470.675.200.425
D10.570.877.360.612.200.425
Definition English:   Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease. 
Indexing Annotation English:   /biosyn /physiol permitted
History Note English:   91(79); was see under GLYCOSPHINGOLIPIDS 1979-90 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
urine  
Record Number:   6060 
Unique Identifier:   D005915 

Occurrence in VHL:
 

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