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INTERLEUKIN-12
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DeCS
Descriptor
English
:
Interleukin-12
Descriptor
Spanish
:
Interleucina-12
Descriptor
Portuguese
:
Interleucina-12
Synonyms
English
:
Edodekin alfa
IL-12
Natural Killer Cell Stimulatory Factor
Tree Number:
D12.644.276.374.465.512
D12.776.467.374.465.512
D23.529.374.465.512
Definition
English
:
A heterodimeric cytokine that plays a
role
in innate and adaptive immune responses.
Interleukin-12
is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by
DENDRITIC CELLS
;
MACROPHAGES
and a variety of other immune
cells
and plays a
role
in the stimulation of INTERFERON GAMMA production by
T-LYMPHOCYTES
and NATURAL
KILLER CELLS.
Indexing Annotation
English
:
DF: IL 12 or IL12
Pharmacological Action:
Adjuvants, Immunologic
Angiogenesis Inhibitors
See Related
English
:
Immunity, Cellular
History Note
English
:
1995(1995)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
32173
Unique Identifier:
D018664
Occurrence in VHL
:
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